In India severe anaemia in patients suffering from Plasmodium falciparum (Pf) is an important concern1. Direct destruction of RBCs following Pf infection cannot account for the degree of anaemia

from Plasmodium falciparum (Pf) is an important concern1. Direct destruction of RBCs following Pf infection cannot account for the degree of anaemia observed during malaria infection instead it has been suggested that the destruction of uninfected RBCs is a major cause of haemoglobin loss2. Recent evidence suggests that RBC complement regulatory proteins are involved in malaria associated anaemia3,4. The complement cascade plays a key role in the modulation of inflammatory responses and its activation has been reported to be crucial to Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India